We are investigating post-transcriptional gene regulation in mammalian cells. In particular, we try to decipher the molecular mechanism and the biological and medical implications of nonsense-mediated mRNA decay (NMD). NMD is an important mRNA quality control process that recognizes and degrades mRNPs that fail to properly terminate translation, but also regulates expression levels of many physiological mRNAs.
Detailed Research Summary
This group is part of the Swiss National Focus in Research on
RNA & Disease jointly hosted by the University of Bern and the ETH Zürich
and directed by Oliver Mühlemann.