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Department of Chemistry and Biochemistry
Freiestrasse 3
CH-3012 Berne

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Publications since 2001

  • Georg Stoecklin & Oliver Mühlemann (2013). RNA decay mechanisms: Specifcity through diversity (Editorial for special issue on RNA decay mechanisms).
    Biochim. Biophys. Acta, in press, doi:10.1016/j.bbagrm.2013.04.002.

  • Silvia Vivarelli, Silvia C. Lenzken, Marc-David Ruepp, Francesco Ranzini, Andrea Maffioletti, Reinaldo Alvarez, Oliver Mühlemann, Silvia M. L. Barabino (2013). Paraquat Modulates Alternative Pre-mRNA Splicing by Modifying the Intracellular Distribution of SRPK2.
    PLOS ONE, April 2013 | Volume 8 | Issue 4 | e61980

  • Christoph Schweingruber, Simone Rufener, David Zünd, Akio Yamashita and Oliver Mühlemann (2013). Nonsense-mediated mRNA decay – mechanisms of substrate mRNA recognition and degradation in mammalian cells.
    BBA – Gene Regulatory Mechanisms, advanced online publication, doi: 10.1016/j.bbagrm.2013.02.005.

  • Oliver Mühlemann (2012). Intimate liaison with SR proteins brings exon junction complexes to unexpected places.
    Nat Struct Mol Biol., 19(12):1209-11

  • Pamela Nicholson, Raphael Joncourt and Oliver Mühlemann (2012). Analysis of Nonsense-Mediated mRNA Decay in Mammalian Cells.
    Current Protocols in Cell Biology 27.4.1-27.4.61.

  • Oliver Mühlemann and Torben Jensen (2012). mRNP quality control goes regulatory.
    Trends in Genetics, 28:70-77.

  • Hasmik Yepiskoposyan, Florian Aeschimann, Daniel Nilsson, Michal Okoniewski and Oliver Mühlemann (2011). Autoregulation of the nonsense-mediated mRNA decay pathway in human cells.
    RNA 17:2108-2118

  • Valeria de Turris, Pamela Nicholson, Rodolfo Zamudio Orozco, Robert H. Singer and Oliver Mühlemann (2011). Cotranscriptional effect of a premature termination codon revealed by live-cell imaging.
    RNA 17:2094-2107

  • Eric Aeby, Elisabetta Ullu, Hasmik Yepiskoposyan, Bernd Schimanski, Isabel Roditi, Oliver Mühlemann and André Schneider (2010). tRNASec is transcribed by RNA polymerase II in Trypanosoma brucei but not in humans.
    Nucleic Acids Research, 38:5833–5843

  • Pamela Nicholson and Oliver Mühlemann (2010). Cutting the nonsense: the degradation of PTC containing mRNAs.
    Biochem. Soc. Trans. 38, part 6

  • Oliver Mühlemann & Jens Lykke-Andersen (2010). How and where are nonsense mRNAs degraded in mammalian cells?
    RNA Biol. 7(1):28-32.
  • Pamela Nicholson, Hasmik Yepiskoposyan, Stefanie Metze, Rodolfo Zamudio Orozco, Nicole Kleinschmidt and Oliver Mühlemann (2009). Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors.
    Cell. Mol. Life Sci. 67:677-700.
  • Lukas Stalder and Oliver Mühlemann (2009). Processing bodies are not required for mammalian nonsense-mediated mRNA decay.
    RNA 7:1265-73.
  • Andrea B Eberle, Herrmann K, Hans-Martin Jäck, Oliver Mühlemann (2009). Equal transcription rates of productively and nonproductively rearranged immunoglobulin mu heavy chain alleles in a pro-B cell line.
    RNA 6:1021-8.
  • Andrea B Eberle, Soren Lykke-Andersen, Oliver Mühlemann and Torben Heick Jensen (2008). SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells.
    Nature Structural & Molecular Biology: doi:10.1038/nsmb.1530

  • Oliver Mühlemann, Andrea Eberle, Lukas Stalder and Rodolfo Zamudio Orozco (2008). Recognition and elimination of nonsense mRNA.
    BBA-GRM 1779:538-49.
  • Lukas Stalder and Oliver Mühlemann (2008). Opinion article: The meaning of nonsense.
    Trends Cell Biol. 18:315-21.
  • Oliver Mühlemann (2008). Recognition of nonsense mRNA: towards a unified model.
    Biochem. Soc. Trans. 36:497-501.
  • Andrea Eberle, Lukas Stalder, Hansruedi Mathys, Rodolfo Zamudio Orozco and Oliver Mühlemann (2008). Posttranscriptional Gene Regulation by Spatial Rearrangement of the 3′ Untranslated Region.
    PLoS Biology, 6(4):e92.
  • Lukas Stalder and Oliver Mühlemann (2007). Transcriptional Silencing of Nonsense Codon - Containing Immunoglobulin µ Genes Requires Translation of its mRNA.
    J. Biol. Chem., 282:16079-85.
  • Lukas Stalder, Andrea Eberle and Oliver Mühlemann (2007). Quality control of gene expression: recognition of nonsense mRNAs prevents synthesis of truncated proteins.
    BioForum Europe, 11:21-23.
  • Marc Bühler, Silvia Steiner, Fabio Mohn, Alexandra Paillusson and Oliver Mühlemann (2006). EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length.
    Nature Struct. Mol. Biol. 13:462-464.

  • Sarah Newbury, Oliver Mühlemann and Georg Stoecklin (2006). Turnover in the Alps; an mRNA perspective. Review of EMBO Workshop on Mechanisms and Regulation of mRNA Turnover.
    EMBO Reports, 7:143-48.
  • Oliver Mühlemann (2005). News & Views: Applying the brakes on gene expression.
    Nature Struct. Mol. Biol. 12:1024-25.

  • Marc Bühler, Fabio Mohn, Lukas Stalder and Oliver Mühlemann (2005). Transcriptional silencing of nonsense codon-containing immunoglobulin minigenes.
    Mol. Cell, 18:307-317.
  • Alexandra Paillusson, Nadine Hirschi, Claudio Vallan, Claus M. Azzalin
    and Oliver Mühlemann (2005). A GFP-based reporter system to monitor nonsense-mediated mRNA decay.
    Nucleic Acids Research, 33: e54
  • Fabio Mohn, Marc Bühler and Oliver Mühlemann (2005). Nonsense-associated alternative splicing of T-cell receptor beta genes: No evidence for frame dependence.
    RNA 11:147-156.
  • Marc Bühler aned Oliver Mühlemann (2005). Alternative splicing induced by nonsense mutations in the immunoglobulin mu VDJ exon is independent of truncation of the open reading frame.
    RNA 11:139-146.
  • Marc Bühler, Alexandra Paillusson and Oliver Mühlemann (2004). Efficient downregulation of immunoglobulin mu mRNA with premature translation-termination codons requires the 5'-half of the VDJ exon.
    Nucleic Acids Res. 32:3304-3315.

  • Marc Bühler, Miles F. Wilkinson and Oliver Mühlemann (2002). Intranuclear degradation of nonsense codon-containing mRNA.
    EMBO Reports 3:646-651

  • Georg Stoecklin, Xiu-Fen Ming, Pascal Stoeckle, Min Lu, Oliver Mühlemann and Christoph Moroni (2001). A Common mRNA Degradation Pathway Targets Structurally Different Cytokine AU-rich Elements.
    RNA 7:1578-1588.

  • Oliver Mühlemann, Caroline S. Mock-Casagrande, Jun Wang, Noélia Custódio, Shulin Li, Maria Carmo-Fonseca, Miles F. Wilkinson and Melissa J. Moore (2001). Precursor RNAs harboring nonsense codons accumulate near the site of transcription.
    Mol. Cell 8:33-44.
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